Protein Modification Reagents
Medchemexpress LLC NHPI-PEG4-C2-Pfp ester | 2101206-46-4 | MFCD28899317 | ≥97.0% | 577.45 g/mol | C25H24F5NO9 | 250 MG
NHPI-PEG4-C2-Pfp ester is a pentafluorophenyl-activated ester containing an N-hydroxyphthalimide-PEG4-C2 spacer. It is supplied as a high-purity research reagent used as a reactive linker intermediate for antibody-drug conjugate (ADC) synthesis and bioconjugation applications.
- Purity ≥97.0% (NMR)
- CAS number 2101206-46-4
- Molecular weight 577.45 g/mol
- Chemical formula C25H24F5NO9
- Used as a reactive linker for antibody-drug conjugates and bioconjugation
- Recommended storage: -20°C for up to 3 years; in solvent -80°C for up to 6 months
STA Pharmaceutical Fmoc-NH-PEG5-CH2COOH | 1 g | CAS 635287-26-2 | InChIKey LNIFRTLAPAPKAG-UHFFFAOYSA-N
Fmoc-NH-PEG5-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 1 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 635287-26-2
- MDL: No data
- InChIKey: LNIFRTLAPAPKAG-UHFFFAOYSA-N
- Molecular Weight: 517.575
- Molecular Formula: C27H35NO9
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC N3-PEG3-vc-PAB-MMAE | 99.1% | 1352.66 | C67H109N13O16 | 5 MG
N3-PEG3-vc-PAB-MMAE is an azide-functionalized drug-linker for antibody-drug conjugate research that combines a PEG3 spacer, a valine-citrulline cleavable peptide with a p-aminobenzyl self-immolative spacer, and the cytotoxic payload monomethyl auristatin E (MMAE). It is designed for bioorthogonal conjugation and ADC construction, supplied as a white to off-white solid with high purity.
- Azide-functionalized for CuAAC and SPAAC conjugation.
- Peg3 spacer improves solubility and flexibility of conjugates.
- Valine-citrulline-PAB linker enables enzymatic release of payload.
- MMAE payload provides potent antimitotic activity.
- High molecular weight (1352.66) supports defined stoichiometry in ADCs.
- High purity (~99.1%) reduces impurities in conjugation reactions.
- Powder stable at -20°C (3 years) and 4°C (2 years); prepare fresh in solution.
ABclonal Technology PEG3 Rabbit pAb
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5 exons and a common promoter and both genes are paternally expressed (PMID15203203). Alternative splicing events connect their shared 5 exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Medchemexpress LLC Dspe-peg-amine ammonium | 474922-26-4 | 99.5% | 1,000 g/mol (average) | (C2H4O)nN2O10P.NH3 | 250 MG
DSPE-PEG-Amine (average MW 1,000, ammonium salt) is a PEGylated phosphoethanolamine lipid bearing a terminal primary amine. It is formulated for incorporation into liposomes, micelles, and other nanoparticle systems to introduce reactive surface amines for covalent conjugation, targeting ligand attachment, and to provide steric stabilization in delivery research.
- Provides a primary amine terminus for bioconjugation.
- Incorporates into lipid bilayers and micelles for surface functionalization.
- Provides PEG steric stabilization to improve circulation and reduce aggregation.
- Suitable for covalent coupling to proteins, dyes, or targeting ligands.
- Average molecular weight 1,000 g/mol, polymeric PEG repeat unit.
- Recommend frozen, sealed storage and protection from moisture.
eMolecules 1189112-05-7 | PEG15 | Broadpharm | MFCD09910394 | 634.757 | C28H58O15 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 229582486
PEG15 | Broadpharm | 1189112-05-7 | MFCD09910394 | 634.757 | C28H58O15 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 229582486
Medchemexpress LLC (S,R,S)-AHPC-PEG2-NH2 | 2010159-60-9 | 95.4% | 575.72 g·mol⁻¹ | C28H41N5O6S | 50 MG
(S,R,S)-AHPC-PEG2-NH2 is an E3 ligase VHL ligand-linker conjugate that links an (S,R,S)-configured AHPC VHL ligand to a two-unit polyethylene glycol (PEG2) spacer ending in a primary amine, used as a building block in PROTAC synthesis.
- VHL ligand-linker conjugate for targeted protein degradation research.
- Contains an (S,R,S)-configured AHPC VHL ligand.
- Features a two-unit PEG linker terminating in a primary amine for conjugation.
- Provided as a free base solid, typically white to yellow.
- Available in small research pack sizes suitable for synthesis workflows.
- High reported purity appropriate for medicinal chemistry and probe synthesis.
Medchemexpress LLC m-PEG-DMG (MW 2000) | 1019000-64-6 | 98.0% | 2000 (average) | No fixed chemical formula - polymeric m-PEG-DMG (average MW 2000) | 10 MG
m-PEG-DMG (MW 2000) is a methoxy-terminated polyethylene glycol conjugated to dimyristoyl glycerol, provided as a solid PEGylated lipid for formulation research. It is used to prepare liposomes and lipid nanoparticles for drug delivery studies, and is supplied at an average molecular weight of 2000 with high purity for reliable experimental results.
- PEGylated lipid for liposome and lipid nanoparticle formulation.
- Average molecular weight 2000 for consistent PEG chain length.
- High purity (~98.0%) suitable for research applications.
- White to off-white solid, easy to handle in laboratory settings.
- Stable when stored as a powder at low temperatures for extended shelf life.
Cayman Chemical BIOnT PROTAC FRGmnt lbrar 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Medchemexpress LLC Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 1-[5-methoxy-2-nitro-4-[(4-oxo-8,11,14,17-tetraoxa-5-aza... | 1802907-98-7 | 95.0% | 653.63 g/mol | C29H39N3O14 | 50 MG
PC Alkyne-PEG4-NHS ester is a cleavable 4-unit PEG linker containing an alkyne group and an N-hydroxysuccinimide (NHS) ester, used for bioconjugation and click-chemistry applications such as antibody-drug conjugate synthesis.
- Cleavable 4-unit polyethylene glycol spacer for improved solubility.
- Alkyne functional group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- NHS ester reactive toward primary amines for efficient conjugation.
- Typical purity 95.0%.
- Storage: pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Methyltetrazine-PEG5-methyltetrazine | 00-00-0 | 98.8% | 704.78 g/mol | C34H44N10O7 | 5 MG
Methyltetrazine-PEG5-methyltetrazine is a homobifunctional PEG-based linker bearing methyltetrazine groups at both termini. It is intended for bioorthogonal inverse electron demand Diels-Alder (iEDDA) click chemistry and as a linker in conjugation workflows; supplied as a solid for research use.
- Homobifunctional methyltetrazine groups enable rapid iEDDA click reactions.
- PEG5 spacer provides a flexible, hydrophilic linkage between reactive ends.
- High purity (~98.8%) suitable for research applications.
- Useful for PROTAC synthesis and biomolecule labeling workflows.
- Purple to purplish red solid, easy to handle and weigh.
- Soluble in DMSO; suggested concentration 100 mg/mL.
- Store powder at -20 °C for long-term stability.
- In solution, store at -80 °C for up to 6 months or -20 °C for up to 1 month.
- For research use only; not for human or therapeutic use.
eMolecules 9004-74-4 | m-PEG24-alcohol | Broadpharm | MFCD27977524 | 1089.314 | C49H100O25 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 229582254
m-PEG24-alcohol | Broadpharm | 9004-74-4 | MFCD27977524 | 1089.314 | C49H100O25 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 229582254
eMolecules 1807503-89-4 | Benzyl-PEG5-CH2CO2tBu | Broadpharm | MFCD28122960 | 398.496 | C21H34O7 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCOCc1ccccc1 | 1g | 254745489
Benzyl-PEG5-CH2CO2tBu | Broadpharm | 1807503-89-4 | MFCD28122960 | 398.496 | C21H34O7 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCOCc1ccccc1 | 1g | 254745489
Medchemexpress LLC DSPE-PEG-DBCO sodium | 95.0% | 5000 (average) | 25 MG
DSPE-PEG-DBCO sodium (MW 5000) is a PEGylated phospholipid supplied as the sodium salt with an average PEG molecular weight of 5000. It is provided as a solid (white to yellow) for use in nanoparticle and liposome functionalization where copper-free click chemistry is required to attach azide-bearing ligands for targeting or payload conjugation.
- Enables copper-free click conjugation via DBCO chemistry.
- Suitable for surface functionalization of lipid nanoparticles and liposomes.
- Provides PEG shielding to improve circulation and reduce opsonization.
- Supplied as a solid with reported purity ~95.0%.
- Average molecular weight 5000 for extended PEG chains and steric stabilization.
eMolecules 1839049-33-0 | DBCO-C2-alcohol | Broadpharm348.402 | C21H20N2O3 | 98.000 | OCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 550804611
DBCO-C2-alcohol | Broadpharm | 1839049-33-0348.402 | C21H20N2O3 | 98.000 | OCCNC(=O)CCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 250mg | 550804611